Methyl D-prolinate → HCID 53704324、化合物
反応式
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[NH:8][CH2:9][CH2:10][S:11][C:12](OC2C=CC([N+]([O-])=O)=CC=2)=[O:13])C=CC=CC=1.[CH3:36][O:37][C:38](=[O:44])[C@H:39]1[CH2:43][CH2:42][CH2:41][NH:40]1>>[CH3:36][O:37][C:38]([C@H:39]1[CH2:43][CH2:42][CH2:41][N:40]1[C:12]([S:11][CH2:10][CH2:9][NH2:8])=[O:13])=[O:44]参加物
3
実験手順
N-triphenylmethyl-2-paranitrophenoxycarbonylthioethylamine (675 mg) and D-proline methylester (0.18 g) were subjected to similar reactions to those described in References 2 and 4 to give 2-[(R)-2-methoxycarbonylpyrrolidino]carbonylthioethylamine (crude formate: 336 mg). The product was dissolved in anhydrous methanol (6 ml). To the solution were added triethylamine (1.01 ml) and mitomycin A (338 mg: 0.8 molar equivalent). The solution was then treated in a similar manner to that described in Example 1 to obtain Compound 32 (286 mg) in the form of grayish blue powders with a yield of 43%.
出典と根拠
- ORDレコード
- ord-893da8e940dd466a838a23e70fa40be3
- 出典データセット
- uspto-grants-1989_09