Formic Acid → 2-Methylaminocarbonylthioethylamine (formate)
反応式
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[NH:8][CH2:9][CH2:10][S:11][C:12]([NH:14][CH3:15])=[O:13])C=CC=CC=1.[CH:28]([OH:30])=[O:29]>>[CH:28]([OH:30])=[O:29].[CH3:15][NH:14][C:12]([S:11][CH2:10][CH2:9][NH2:8])=[O:13]参加物
3
反応条件
- 温度
- 50 °C
実験手順
To N-triphenylmethyl-2-methylaminocarbonylthioethylamine (306 mg) which was prepared by the method of Reference 2 was added formic acid (98%; 5 ml). The reaction solution was stirred at a temperature of 50° C. for 30 minutes and was then concentrated under reduced pressure. The resultant residue was purified without after-treatment by silica gel chromatography using a solvent system of chloroform/methanol/water (6:5:1 v/v) to obtain 139 mg of the desired product with a yield of 95%.
後処理
- concentrationwas then concentrated under reduced pressure
- customThe resultant residue was purified without after-treatment by silica gel chromatography
出典と根拠
- ORDレコード
- ord-1659411165b0411b8063ca1665ed9be6
- 出典データセット
- uspto-grants-1989_09
- 特許番号
- US04863935
反応ノート
読み込み中…