Dimethyl Sulfate → 1,2-Dimethyl-1H-imidazole-5-carboxylic acid

HRID 1607312ノート

反応式

HRID 1607312 の反応式
S(OC)(OC)(=O)=O.[CH3:8][N:9]1[C:13]([C:14]([O:16]C)=[O:15])=[CH:12][N:11]=[C:10]1[CH3:18]>>[CH3:8][N:9]1[C:13]([C:14]([OH:16])=[O:15])=[CH:12][N:11]=[C:10]1[CH3:18]

参加物

3

反応物 2

HCID 6497Dimethyl SulfateHCID 14344426Methyl 1,2-dimethyl-1H-imidazole-5-carboxylate

生成物 1

HCID 233618731,2-Dimethyl-1H-imidazole-5-carboxylic acid収率 67%

実験手順

In the manner described in Example 1 126 g (1 mol) of 2-methylimidazole-4(5)-carboxylic acid was treated with dimethyl sulfate and the product was converted into its methyl ester for characterization. This gave 103.3 g of methyl 1,2-dimethylimidazole-5-carboxylate, m.p. 38°-40° C., an overall yield of 67%.

出典と根拠

ORDレコード
ord-eed292a70e304ba7b0b778555e3424ad
出典データセット
uspto-grants-1989_09
特許番号
US04864030

反応ノート

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