Morpholine → 4-[(4-Bromo-2,5-difluorophenyl)sulfonyl]-morpholine

HRID 16074

反応式

HRID 16074 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Br:7][C:8]1[C:13]([F:14])=[CH:12][C:11]([S:15](Cl)(=[O:17])=[O:16])=[C:10]([F:19])[CH:9]=1>ClCCl>[Br:7][C:8]1[C:13]([F:14])=[CH:12][C:11]([S:15]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)(=[O:16])=[O:17])=[C:10]([F:19])[CH:9]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 5745904-Bromo-2,5-difluorobenzenesulfonyl Chloride

生成物 1

HCID 686063584-[(4-Bromo-2,5-difluorophenyl)sulfonyl]-morpholine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Morpholine (0.16 ml) was added to a stirred solution of 4-bromo-2,5-difluoro-benzenesulfonyl chloride (0.18 g) in dichloromethane (6 ml) under nitrogen. The reaction mixture was stirred overnight and then quenched with water. The organic phase was dried (MgSO4) and concentrated in vacuo to give the sub-title compound as a white solid (200 mg).

後処理

  1. customquenched with water
  2. dry with materialThe organic phase was dried (MgSO4)
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-39a68fdc2cf342168e2bccff054cfd0b
出典データセット
uspto-grants-2010_06
特許番号
US07737135B2

関連ノート

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