Ethyl 3-hydroxy-2-methylprop-2-enoate → 2-phenylthio-6-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one

HRID 1607538ノート

反応式

HRID 1607538 の反応式
[NH2:1][C:2]1[S:3][C:4]([S:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:5][N:6]=1.[OH:14][CH:15]=[C:16]([CH3:22])[C:17](OCC)=O>>[C:8]1([S:7][C:4]2[S:3][C:2]3=[N:1][CH:17]=[C:16]([CH3:22])[C:15](=[O:14])[N:6]3[N:5]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

3

反応物 2

HCID 521546Ethyl 3-hydroxy-2-methylprop-2-enoateHCID 146950682-Amino-5-phenylthio-1,3,4-thiadiazole

生成物 1

HCID 156107852-phenylthio-6-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one収率 58%

実験手順

Seven point two (7.2) g of the thus obtained 2-amino-5-phenylthio-1,3,4-thiadiazole and 4.9 g of ethyl 3-hydroxy-2-methyl-2-propenoate were mixed with 13 g of polyphosphoric acid. By the same procedure as in Preparation Example 4, 5.9 g of 2-phenylthio-6-methyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was obtained.

後処理

  1. customBy the same procedure as in Preparation Example 4

出典と根拠

ORDレコード
ord-acdd4860f7054f37afedfc76e0877ab5
出典データセット
uspto-grants-1989_09
特許番号
US04866064

反応ノート

読み込み中…