Fumarate → 5-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

HRID 1607594ノート

反応式

HRID 1607594 の反応式
[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][CH:3]=1.[C:13]([O-])(=O)/C=C/C([O-])=O>>[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH2:8][N:9]([CH3:13])[CH2:10][CH2:11][CH:12]=2)=[N:4][CH:3]=1

参加物

3

反応物 2

HCID 5460307FumarateHCID 196125135-Methyl-2-(3-pyridyl)-thiazole

生成物 1

HCID 196124795-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

実験手順

The title compound was prepared from 88 (2.2 g, 0.013 mol) by the procedure described in Example 49. The crude free base obtained, 89, was converted to the title fumarate, 90. Yield: 0.8 g (0.0032 mol, 25%). M.P. 159°-160° C. Anal. (C12H16N2O2S)C, H, N.

後処理

  1. customThe crude free base obtained

出典と根拠

ORDレコード
ord-20be5756eb964adc8d62a76ecbb0ba26
出典データセット
uspto-grants-1989_09
特許番号
US04866077

反応ノート

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