2,6-Diisopropylphenyl isocyanate → 1-Chroman-3-yl-3-(2,6-diisopropyl-phenyl)-urea

HRID 1607926ノート

反応式

HRID 1607926 の反応式
[NH2:1][CH:2]1[CH2:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[O:4][CH2:3]1.[CH3:12][CH:13]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]([CH3:23])[CH3:22])[C:16]=1[N:24]=[C:25]=[O:26])[CH3:14]>C(OCC)(=O)C>[CH3:14][CH:13]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH:21]([CH3:22])[CH3:23])[C:16]=1[NH:24][C:25]([NH:1][CH:2]1[CH2:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[O:4][CH2:3]1)=[O:26])[CH3:12]

参加物

4

反応物 2

HCID 922592,6-Diisopropylphenyl isocyanateHCID 2057093,4-Dihydro-3-amino-2H-1-benzopyran

生成物 1

HCID 145552481-Chroman-3-yl-3-(2,6-diisopropyl-phenyl)-urea収率 59.1%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 3,4-dihydro-3-amino-2H-benzopyran (0.9 g, 6 mmole) in 50 ml of ethyl acetate, there was added 1.22 g (6 mmol) of 2,6-bis(1-methylethyl)phenyl isocyanate. The resulting mixture was stirredat room temperature for twenty hours. The solvent was removed under vacuum and the residue was suspended in 20% ethyl acetate/hexane. The precipitated solid was collected by filtration and dried to yield 1.25 g of N-[2,6-bis(1-methylethyl)phenyl]-N'-(3,4-dihydro-2H-benzopyran-3-yl)urea, mp 186°-188° C.

後処理

  1. waitThe resulting mixture was stirredat room temperature for twenty hours
  2. customThe solvent was removed under vacuum
  3. filtrationThe precipitated solid was collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-fdf2a7480eb9486584f57f10126f4f10
出典データセット
uspto-grants-1989_09
特許番号
US04868210

反応ノート

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