Aluminum(III) Chloride → HCID 178454735、化合物

HRID 1607991

反応式

HRID 1607991 の反応式
[OH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:11][CH:12]([CH2:16][C:17]([O:19]C)=[O:18])[C:13](Cl)=[O:14].[Cl-].[Al+3].[Cl-].[Cl-]>C(=S)=S>[C:17]([CH2:16][CH:12]([CH3:11])[C:13]([C:8]1[CH:9]=[CH:10][C:4]2[N:3]=[C:2]([OH:1])[NH:6][C:5]=2[CH:7]=1)=[O:14])([OH:19])=[O:18]

参加物

5

反応物 3

HCID 6451240Aluminum(III) ChlorideHCID 14403282Methyl 4-chloro-3-methyl-4-oxobutanoateHCID 178517141HCID 178517141、化合物

生成物 1

HCID 178454735HCID 178454735、化合物

試薬・触媒・溶媒 1

HCID 6348Carbon Disulfide溶媒

実験手順

Carbon disulfide (90 ml), 2-hydroxybenzimidazole (4.1 g) and 2-methyl-3-carbomethoxy propionyl chloride (5 g) are added to aluminum chloride (20.3 g) under nitrogen. The resulting mixture is refluxed for about 45 hours, quenched with ice cold 6N HCl and the acidic mixture filtered. The filtered solid is washed with water and dried in vacuo, affording the desired product as a solid, M.P. 223° C. (dec).

後処理

  1. temperatureThe resulting mixture is refluxed for about 45 hours
  2. customquenched with ice cold 6N HCl
  3. filtrationthe acidic mixture filtered
  4. washThe filtered solid is washed with water
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-849530c707db4dce81f27bf7b508f13e
出典データセット
uspto-grants-1989_09
特許番号
US04868300

関連ノート

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