化工社化工社 化学情報印刷レポート · 研究参考用
Malononitrile → Dihydro-2H-pyran-4,4(3H)-dicarbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Malononitrile | HCID 8010 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,1'-Oxybis(2,2-dichloroethane) | HCID 62383 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Dihydro-2H-pyran-4,4(3H)-dicarbonitrile | HCID 14537194 | — |
反応手順
According to Flowchart I dichloroethyl ether (1) is reacted with malononitrile (2) in the presence of potassium carbonate in acetonitrile at reflux, giving tetrahydro-4H-pyran-4,4-dicarbonitrile (3) which is then reduced with 1N borane in tetrahydrofuran followed by treatment with hydrochloric acid, giving tetrahydro-4H-pyran-4,4-dimethanamine dihydrochloride (4) which is then reacted with a mixture of sodium acetate and potassium tetrachloroplatinate in water, giving the intermediate compound dichloro(tetrahydro-4H-pyran-4,4-dimethanamine-N,N')platinum (5). ##STR9##
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04870070 |
| 出典データセット | uspto-grants-1989_09 |
| ORD ID | ord-ceed7ac1368e4664b31ade80bc10b40d |
| 出典メモ | uspto-grants-1989_09 |