Nicotinic acid, hydrazide → Nicotinic acid (4-quinolinylmethylene)hydrazide

HRID 1608178

反応式

HRID 1608178 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=O)=[CH:3][CH:2]=1.[C:13]([NH:21][NH2:22])(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[N:16][CH:15]=1>C(O)C>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=[N:22][NH:21][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[N:16][CH:15]=2)=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 11112Nicotinic acid, hydrazideHCID 780724-Quinolinecarboxaldehyde

生成物 1

HCID 73067006Nicotinic acid (4-quinolinylmethylene)hydrazide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 7.86 gm (0.05 mole) of 4-quinolinecarboxaldehyde, 6.86 gm (0.05 mole) of nicotinic acid hydrazide and 100 ml of ethanol is refluxed 2 hr. The reaction mixture is cooled to room temperature. The solid which sepatates is collected, washed with water and dried; 14.4 gm (quantitative) to give the title compound; mp. 99.6° C. The product is recrystallized from ethanol to give 11.54 gm (83%) of the title compound, having a melting point of 192.7° C.

後処理

  1. temperatureis refluxed 2 hr
  2. customThe solid which sepatates is collected
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-13af637d027f4161b37957f27ddb3bfd
出典データセット
uspto-grants-1989_09
特許番号
US04870082

関連ノート

読み込み中…