Dimethyl Sulfoxide → 4-Benzyl-2-morpholineacetonitrile

HRID 1608215ノート

反応式

HRID 1608215 の反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14]Cl)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C-:16]#[N:17].[K+].CS(C)=O>O.[I-].[K+]>[CH2:1]([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][C:16]#[N:17])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 679Dimethyl SulfoxideHCID 9032Potassium CyanideHCID 28015624-Benzyl-2-(chloromethyl)morpholine

生成物 1

HCID 32484164-Benzyl-2-morpholineacetonitrile収率 92.8%

試薬・触媒・溶媒 2

HCID 4875Potassium Iodide触媒HCID 962Water溶媒

反応条件

温度
120 °C

実験手順

A mixture of 4-benzyl-2-chloromethylmorpholine (22.5 g), potassium cyanide (13 g), potassium iodide (1 g), and dimethyl sulfoxide (40 ml) is heated with stirring at 120° C. for 5 hours. The reaction mixture is cooled, diluted with water, and extracted with diethyl ether. The organic layer is washed with water, dried over sodium sulfate, and evaporated to give the title compound (20 g) as an oil.

後処理

  1. temperatureis heated
  2. temperatureThe reaction mixture is cooled
  3. extractionextracted with diethyl ether
  4. washThe organic layer is washed with water
  5. dry with materialdried over sodium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-41e789ef8c1144c2a2c531ef8c2002fc
出典データセット
uspto-grants-1989_09
特許番号
US04870074

反応ノート

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