Water → 2-(4-Benzylmorpholin-2-yl)ethan-1-ol

HRID 1608216ノート

反応式

HRID 1608216 の反応式
C([O:3][C:4]([CH2:6][CH:7]1[O:12][CH2:11][CH2:10][N:9]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8]1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(OCC)(=O)C.O>C(OCC)C>[OH:3][CH2:4][CH2:6][CH:7]1[O:12][CH2:11][CH2:10][N:9]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8]1

参加物

6

反応物 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 12582571Ethyl (4-benzylmorpholin-2-yl)acetateHCID 21226445Aluminium lithium hydride2 回

生成物 1

HCID 146525912-(4-Benzylmorpholin-2-yl)ethan-1-ol収率 99.8%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

反応条件

温度
25 °C

実験手順

A solution of 2-ethoxycarbonylmethyl-4-benzylmorpholine (41 g) in diethyl ether (100 ml) is added dropwise to a stirred suspension of lithium aluminum hydride (59.2 g) in diethyl ether (150 ml). The reaction mixture is stirred at 25° C. for 1 hour. The excess of lithium aluminum hydride is decomposed by the successive addition of ethyl acetate and water. The insoluble materials are filtered off, and the filtrate is evaporated to give the title compound (34.4 g) as an oil. The starting material, 2-ethoxycarbonylmethyl-4-benzylmorpholine, is prepared according to the method of F. Loftus [Syn. Commun., 10, 59-73 (1980)].

後処理

  1. filtrationThe insoluble materials are filtered off
  2. customthe filtrate is evaporated

出典と根拠

ORDレコード
ord-38c5b70e8f36445eab66d2f41d246acf
出典データセット
uspto-grants-1989_09
特許番号
US04870074

反応ノート

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