Acetic Anhydride → HCID 19848591、化合物

反応式

[OH:1][CH2:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:5]1.C(N(CC)CC)C.[C:24](OC(=O)C)(=[O:26])[CH3:25]>C(OCC)(=O)C>[C:24]([O:1][CH2:2][CH2:3][CH:4]1[O:9][CH2:8][CH2:7][N:6]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:5]1)(=[O:26])[CH3:25]

参加物

反応条件

温度: 25 °C

実験手順

To a mixture of 2-(2-hydroxyethyl)-4-benzylmorpholine (27.7 g), triethylamine (28 ml), and ethyl acetate (100 ml) is dropwise added acetic anhydride (17.8 ml). The reaction mixture is stirred at 25° C. for 1 hour and evaporated under reduced pressure. The residue is dissolved in chloroform and chromatographed on silica gel. Fractions containing the title compound are pooled and evaporated to give the title compound (29.1 g) as an oil.