4-(2-Chlorobenzyl)-2-chloromethyl-6-methylmorpholine → N-[[4-(2-chlorobenzyl)-6-methyl-2-morpholinyl]methyl]phthalimide

HRID 1608226ノート

反応式

HRID 1608226 の反応式
[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[O:8][CH:7]([CH2:12]Cl)[CH2:6]1.[K].[C:19]1(=[O:29])[NH:23][C:22](=[O:24])[C:21]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:20]12>CN(C)C=O>[Cl:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[CH2:4][N:5]1[CH2:10][CH:9]([CH3:11])[O:8][CH:7]([CH2:12][N:23]2[C:22](=[O:24])[C:21]3=[CH:25][CH:26]=[CH:27][CH:28]=[C:20]3[C:19]2=[O:29])[CH2:6]1

参加物

4

反応物 2

HCID 198486194-(2-Chlorobenzyl)-2-chloromethyl-6-methylmorpholineHCID 24194345Phthalimide potassium salt

生成物 1

HCID 19848602N-[[4-(2-chlorobenzyl)-6-methyl-2-morpholinyl]methyl]phthalimide収率 94%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
150 °C

実験手順

A mixture of 4-(2-chlorobenzyl)-2-chloromethyl-6-methylmorpholine (19.7 g), phthalimide potassium salt (14.6 g), and dimethylformamide (150 ml) is stirred at 150° C. for 5 hours. The reaction mixture is poured into ice-water and extracted with diethyl ether. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. The solvent is distilled off to give the title compound (26 g) as an oil.

後処理

  1. extractionextracted with diethyl ether
  2. washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. distillationThe solvent is distilled off

出典と根拠

ORDレコード
ord-b4daf0cac8694cad8489942fe69d50af
出典データセット
uspto-grants-1989_09
特許番号
US04870074

反応ノート

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