Acetic Anhydride → Ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate
反応式
[CH2:1]([O:3][C:4](=[O:20])[CH2:5][C:6](=[O:19])[C:7]1[CH:12]=[C:11]([F:13])[C:10]([Cl:14])=[C:9]([N+:15]([O-:17])=[O:16])[C:8]=1[Cl:18])[CH3:2].[CH:21](OCC)(OCC)[O:22][CH2:23][CH3:24].C(OC(=O)C)(=O)C>>[Cl:18][C:8]1[C:9]([N+:15]([O-:17])=[O:16])=[C:10]([Cl:14])[C:11]([F:13])=[CH:12][C:7]=1[C:6]([C:5](=[CH:21][O:22][CH2:23][CH3:24])[C:4]([O:3][CH2:1][CH3:2])=[O:20])=[O:19]参加物
4
実験手順
244.8 g of ethyl(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-acetate are heated at 150°-160° C. with 166 g of triethyl orthoformate and 185 g of acetic anhydride for 3 hours. The mixture is then concentrated in vacuo and 270 g of ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxy-acrylate are obtained as an oily residue.