(4-Tolylsulphonyl)acetic acid → HCID 67687665、化合物

HRID 1608473ノート

反応式

HRID 1608473 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][C:12]([OH:14])=[O:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(=O)(O)O.[NH2:19][C:20]([NH2:22])=[NH:21]>C(O)C>[NH2:21][C:20]([NH2:22])=[NH2+:19].[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][C:12]([O-:14])=[O:13])(=[O:9])=[O:10])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 77538(4-Tolylsulphonyl)acetic acid2 回HCID 286947Carbonic acid-guanidine (1:1)

生成物 1

HCID 67687665HCID 67687665、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Guanidinium 4-methylphenylsulfonylacetate was prepared as follows: To a mixture of 4.441 g (0.0207 mol) of 4-methylphenylsulfonylacetic acid in 25 mL of ethanol was added 1.867 g (0.0104 mol) of guanidine carbonate and the mixture stirred at room temperature for 18 hr. The resultant product was then filtered off and air dried to afford 5.150 g; mp 152°-153° C. (dec). NMR was in agreement with the proposed structure. The 4-methylphenylsulfonylacetic acid was obtained from Lancaster Synthesis Inc. Windham, N. H.

後処理

  1. filtrationThe resultant product was then filtered off
  2. customair dried
  3. customto afford 5.150 g

出典と根拠

ORDレコード
ord-a0fb1f29601b4f26a1992c358d2dc6f6
出典データセット
uspto-grants-1995_03
特許番号
US05395747

反応ノート

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