Triethylamine → 4-Thiazolemethanol, 2-ethynyl-(9CI)

HRID 1608540ノート

反応式

HRID 1608540 の反応式
Br[C:2]1[S:3][CH:4]=[C:5]([CH2:7][OH:8])[N:6]=1.[Cl-].[NH4+].[CH2:11](N(CC)CC)[CH3:12]>[Cu](I)I.[Pd](Cl)Cl.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[C:11]([C:2]1[S:3][CH:4]=[C:5]([CH2:7][OH:8])[N:6]=1)#[CH:12]

参加物

6

反応物 3

HCID 8471TriethylamineHCID 25517Ammonium ChlorideHCID 2763211(2-Bromo-1,3-thiazol-4-yl)methanol

生成物 1

HCID 450793284-Thiazolemethanol, 2-ethynyl-(9CI)

試薬・触媒・溶媒 2

HCID 83717Copper iodide触媒HCID 6102075Dichlorobis(triphenylphosphine)palladium触媒

実験手順

2-bromo 4-thiazolyl methanol of preparation 39 was reacted with trimethylacetylene in the presence of copper iodide, bis(triphenylphosphine) palladium chloride and triethylamine and then the mixture was poured into an aqueous solution of ammonium chloride to obtain the expected alcohol.

出典と根拠

ORDレコード
ord-6b8b2977c0c04148a5728397ca6830b2
出典データセット
uspto-grants-1995_03
特許番号
US05395845

反応ノート

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