Hydrochloric Acid → 5-[4-(Benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7]-decan-2-amine hydrochloride
反応式
C([NH:20][CH:21]1[CH:28]2[CH2:29][CH:24]3[CH2:25][C:26]([O:31][CH2:32][C:33]4[CH:38]=[CH:37][C:36]([C:39]5[O:40][C:41]6[CH:47]=[CH:46][CH:45]=[CH:44][C:42]=6[N:43]=5)=[CH:35][CH:34]=4)([CH2:30][CH:22]1[CH2:23]3)[CH2:27]2)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:48]>>[ClH:48].[O:40]1[C:41]2[CH:47]=[CH:46][CH:45]=[CH:44][C:42]=2[N:43]=[C:39]1[C:36]1[CH:35]=[CH:34][C:33]([CH2:32][O:31][C:26]23[CH2:30][CH:22]4[CH2:23][CH:24]([CH2:29][CH:28]([CH:21]4[NH2:20])[CH2:27]2)[CH2:25]3)=[CH:38][CH:37]=1参加物
3
実験手順
A mixture of N-trityl-5-[4-(benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7 ]decan-2-amine (200 mg) combined with ethanolic hydrogen chloride (5 ml) is stirred for an hour at room temperature. This is evaporated to dryness and the components separated via flash chromatography (eluting with 10% MeOH/CH2Cl2) to obtain 5-[4-(benzoxazol-2-yl)benzyloxy]tricyclo[3.3.1.13,7 ]-decan-2-amine hydrochloride (m.p. 278°-281° C.).
後処理
- customThis is evaporated to dryness
- customthe components separated via flash chromatography (eluting with 10% MeOH/CH2Cl2)