Potassium Carbonate → 1-[(Benzyloxy)methyl]-2,4,5-tribromoimidazole
反応式
[Br:1][C:2]1[NH:6][C:5]([Br:7])=[N:4][C:3]=1[Br:8].C([O-])([O-])=O.[K+].[K+].Cl[CH2:16][O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CN(C=O)C>[CH2:18]([O:17][CH2:16][N:4]1[C:3]([Br:8])=[C:2]([Br:1])[N:6]=[C:5]1[Br:7])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1参加物
5
実験手順
Tribromoimidazole (2.0 g, 6.6 mmol) in 25 mL of DMF solution was treated with powdered K2CO3 (12.7 g, 91.6 mmol). To the vigorously stirring suspension was added dropwise benzyl chloromethyl ether (1.4 g, 9.2 mmol). After 18 hours, the reaction mixture was filtered. The filtrate was concentrated in vacuo. The residue was chromatographed as described previously. The product was used immediately in Example 39.
後処理
- filtrationthe reaction mixture was filtered
- concentrationThe filtrate was concentrated in vacuo
- customThe residue was chromatographed
出典と根拠
- ORDレコード
- ord-54616f6280b143efb404cbf2998a87ea
- 出典データセット
- uspto-grants-1995_03
- 特許番号
- US05395932
反応ノート
読み込み中…