Triethylamine → 4-[N-(3-Benzyloxypropyl)aminomethyl]-2'-cyanobiphenyl

HRID 1609189ノート

反応式

HRID 1609189 の反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]#[N:16])=[CH:5][CH:4]=1.[CH2:17]([O:24][CH2:25][CH2:26][CH2:27][NH2:28])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(N(CC)CC)C>O1CCOCC1>[CH2:17]([O:24][CH2:25][CH2:26][CH2:27][NH:28][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]#[N:16])=[CH:5][CH:4]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 15019124'-(Bromomethyl)-2-cyanobiphenylHCID 71307843-(Benzyloxy)propan-1-amine

生成物 1

HCID 218404054-[N-(3-Benzyloxypropyl)aminomethyl]-2'-cyanobiphenyl

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A solution of 6.0 g (22 mmol) of 4-bromomethyl-2'-cyanobiphenyl, 5.8 g (35 mmol) of 3-benzyloxypropylamine and 3.6 g of triethylamine in 50 ml of 1,4-dioxane is heated to boiling under reflux for 18 hours. After working up analogously to Example 23a), an oil is obtained which, after flash-chromatographic purification (ethanol:ethyl acetate: 1:4), gives the title compound (TLC system B7; Rf value 0.39).

後処理

  1. temperatureunder reflux for 18 hours
  2. customis obtained which
  3. customafter flash-chromatographic purification (ethanol:ethyl acetate: 1:4)

出典と根拠

ORDレコード
ord-5853fdeb310c4f5eb2d1b1f9fafbbab4
出典データセット
uspto-grants-1995_03
特許番号
US05399578

反応ノート

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