1-(3-Methoxyphenoxy)-2-nitrobenzene → 3-(2-Nitrophenoxy)phenol

HRID 1609259ノート

反応式

HRID 1609259 の反応式
[N+:1]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][C:7]1[CH:8]=[C:9]([O:13]C)[CH:10]=[CH:11][CH:12]=1)([O-:3])=[O:2].Cl.N1C=CC=CC=1>O>[N+:1]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[O:6][C:7]1[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 93111371-(3-Methoxyphenoxy)-2-nitrobenzeneHCID 10176127Pyridinium chloride

生成物 1

HCID 125886933-(2-Nitrophenoxy)phenol収率 87.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 28.8 g of 3-(2-nitrophenoxy)anisole and 68 g of pyridine hydrochloride was heated to 160°-170° C. to prepare a homogeneous solution, which was further heated at 195°-205° C. with stirring for one hour. After cooling, the reaction mixture was diluted with water and extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried and concentrated and the residue was subjected to silica gel and eluted with chloroform to give 23.8 g of the title compound as a light brown oil.

後処理

  1. temperaturewas heated to 160°-170° C.
  2. customto prepare a homogeneous solution, which
  3. temperaturewas further heated at 195°-205° C.
  4. temperatureAfter cooling
  5. extractionextracted with ethyl acetate
  6. washThe ethyl acetate layer was washed with water
  7. customdried
  8. concentrationconcentrated
  9. washeluted with chloroform

出典と根拠

ORDレコード
ord-88446460ee1a4c2996d1b240bab33973
出典データセット
uspto-grants-1995_03
特許番号
US05399703

反応ノート

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