Bromine → 2-Bromo-1-cycloheptylethan-1-one

HRID 1609314ノート

反応式

HRID 1609314 の反応式
[CH3:1][C:2]([CH:4]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=[O:3].[Br:11]Br>CO>[CH:4]1([C:2]([CH2:1][Br:11])=[O:3])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1

参加物

4

反応物 2

HCID 24408BromineHCID 126763521-Cycloheptylethan-1-one

生成物 1

HCID 218423502-Bromo-1-cycloheptylethan-1-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

An ice cold solution of 19.0 g of cycloheptyl methyl ketone in 100 ml of methyl alcohol was treated dropwise with 7 ml of bromine. After 5 min, the ice bath was removed and the reaction mixture was allowed to warm to room temperature. The reaction mixture was then diluted with 500 ml of water and extracted with ethyl ether (3×75 ml). The combined extracts were washed with saturated sodium bicarbonate, brine, dried (MgSO4) and condensed in vacuo to yield 29.9 g of bromomethyl cycloheptyl ketone as an oil.

後処理

  1. customthe ice bath was removed
  2. additionThe reaction mixture was then diluted with 500 ml of water
  3. extractionextracted with ethyl ether (3×75 ml)
  4. washThe combined extracts were washed with saturated sodium bicarbonate, brine
  5. customdried
  6. custom(MgSO4) and condensed in vacuo

出典と根拠

ORDレコード
ord-1a813d8be7df472196973d82b5d1d702
出典データセット
uspto-grants-1995_03
特許番号
US05399702

反応ノート

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