化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Isopropyl 1-methyl-3-indoleacetimidate hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 2-(1-methyl-1H-indol-3-yl)acetonitrile | HCID 10654720 | — |
| 生成物 | Isopropyl 1-methyl-3-indoleacetimidate hydrochloride | HCID 22907276 | 44% |
反応手順
Hydrogen chloride was bubbled through a stirred solution of 7.5 g (44 mmol) of 1-methylindole-3-acetonitrile in 100ml of dry isopropanol at room temperature. After 4 hours, the solvent was removed under reduced pressure and the residue was triturated with diethyl ether to give 5.17 g (44%) of isopropyl 1-methyl-3-indoleacetimidate hydrochloride as a white solid of melting point 133° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05399712 |
| 出典データセット | uspto-grants-1995_03 |
| ORD ID | ord-968189737b3e40409f7af5ed50844dcc |
| 出典メモ | uspto-grants-1995_03 |