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Anthranilic Acid → N-Phenylanthranilic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Anthranilic Acid | HCID 227 | — |
| 反応物 | 2-Bromo-4-methyl-1-nitrobenzene | HCID 8167038 | — |
| 生成物 | N-Phenylanthranilic Acid | HCID 4386 | — |
反応手順
As shown in Scheme 7, coupling of 3-bromo-4-nitrotoluene with 2-amino-benzoic acid via an Ullmann reaction yields an N-phenyl-anthranilic acid. After protection of the acid with 2-amino-2-methyl-1-propanol, oxidation affords the corresponding aldehyde. Addition of vinyl magnesium bromide and deprotection provides the N-phenyl-anthranilic acid containing a latent Michael acceptor. ##STR15##
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05399790 |
| 出典データセット | uspto-grants-1995_03 |
| ORD ID | ord-920e207501f64dc5941e0fe889c060c3 |
| 出典メモ | uspto-grants-1995_03 |