関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Thiopheneacetic acid | HCID 15970 | — |
| 反応物 | Methyl 2-bromo-3-methylbutanoate | HCID 228837 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl 2-acetylthio-3-methylbutanoate | HCID 20081438 | — |
反応手順
Potassium tert-butoxide (20.4 g) was added portionwise with stirring and cooling to thiolacetic acid (13.85 g) in dry dimethylformamide (150 ml). Stirring was continued for five minutes, then methyl 2-bromo-3-methylbutanoate (32.3 g) was added with ice-cooling (about 10° C. internal temperature). After stirring at room temperature overnight, the reaction mixture was diluted with ether (about 1 liter), washed with water (3 times), dried over magnesium sulfate and run down under vacuum. The title product was obtained as an orange oil, 29.2 g (93%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05401710 |
|---|
| 出典データセット | uspto-grants-1995_03 |
|---|
| ORD ID | ord-2e2d480d1ef44d93bef10395f92d73ce |
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| 出典メモ | uspto-grants-1995_03 |
|---|
