関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Pyridinemethanamine | HCID 31018 | — |
| 反応物 | 6-Methoxyphthalide | HCID 330539 | — |
| 生成物 | 2-hydroxymethyl-5-methoxy-N-(3-pyridylmethyl)benzamide | HCID 20082005 | 91.8% |
反応手順
A mixture of 919 mg of 6-methoxyisobenzofuran-1 (3H)-one and 1.82 g of 3-aminomethylpyridine was heated at 150° C. without solvent for 3 hours under stirring. After finishing the reaction, the mixture was chromatographed on a column of silica gel, eluting with ethyl acetate and then with tetrahydrofuran to give 1.40 g of the titled compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05401756 |
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| 出典データセット | uspto-grants-1995_03 |
|---|
| ORD ID | ord-c962d1214f004a7bb3220bdf4e352a35 |
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| 出典メモ | uspto-grants-1995_03 |
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