3-Pyridinemethanamine → 7-(4-chlorophenoxy)-2-(3-pyridylmethyl)-1 (2H)-isoquinolinone

反応式

[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][C:7]2[CH:17]=[C:16]3[C:10]([CH:11]=[CH:12]O[C:14]3=[O:15])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[NH2:20][CH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[CH:17]=[C:16]3[C:10]([CH:11]=[CH:12][N:20]([CH2:21][C:22]4[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=4)[C:14]3=[O:15])=[CH:9][CH:8]=2)=[CH:18][CH:19]=1

参加物

反応物 2

HCID 310183-Pyridinemethanamine

HCID 20082001HCID 20082001、化合物

生成物 1

HCID 152304787-(4-chlorophenoxy)-2-(3-pyridylmethyl)-1 (2H)-isoquinolinone収率 72.9%

反応条件

温度: 180 °C

実験手順

A mixture of 100 mg of 7-(4-chlorophenoxy)isocoumarin and 377 mg of 3-aminomethylpyridine was heated at 180° C. without solvent under stirring for 5 hours. After finishing the reaction, the mixture was chromatographed on a column of silica gel, eluting with ethyl acetate to give 97 mg of the titled compound.

後処理

customthe reaction
customthe mixture was chromatographed on a column of silica gel
washeluting with ethyl acetate

出典と根拠

ORDレコード: ord-d13622414e284897b89799995bfbbd53
出典データセット: uspto-grants-1995_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05401756

反応ノート

読み込み中…