Ethyl Acetate → 1-Propanol, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-, (R)-

HRID 1609785ノート

反応式

HRID 1609785 の反応式
[Si:1]([O:18][CH2:19][C@H:20]([CH3:25])[C:21](OC)=[O:22])([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC(C[AlH]CC(C)C)C.CCCCCC.C(OCC)(=O)C.CC(C[AlH]CC(C)C)C>C1(C)C=CC=CC=1>[Si:1]([O:18][CH2:19][C@H:20]([CH3:25])[CH2:21][OH:22])([C:14]([CH3:16])([CH3:17])[CH3:15])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 14487Diisobutylaluminum hydrideHCID 11302759(2S)-3-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-2-methylpropanoic Acid Methyl EsterHCID 131725251DIBAL n-hexane

生成物 1

HCID 117718171-Propanol, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-2-methyl-, (R)-収率 109.1%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Under argon atmosphere, Methyl(S)-3-(t-butyldiphenylsilyloxy)-2-metylpropionate (47) (1.0 g, 2.7 mmol) was dissolved in 50 ml of dry toluene, 1M DIBAL-H/hexane (5.7 ml, 5.7 mmol) was added to the resultant solution at 0° C., and the mixture was stirred for 15 min. Subsequently, the reaction mixture was further stirred for 45 min after the temperature was returned to room temperature. Ethyl acetate was added to the reaction mixture to decompose the excess DIBAL-H, and the resultant mixture was extracted with 0.5N HCl. The ethyl acetate layer was washed with brine, dried over magnesium sulfate and evaporated. The obtained crude product was purified by column chromatography (30 g, 4-10% AcOEt-hexane) to obtain a colorless oily product (48) (968 mg, quant.).

後処理

  1. stirringSubsequently, the reaction mixture was further stirred for 45 min after the temperature
  2. customwas returned to room temperature
  3. extractionthe resultant mixture was extracted with 0.5N HCl
  4. washThe ethyl acetate layer was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. customevaporated
  7. customThe obtained crude product
  8. customwas purified by column chromatography (30 g, 4-10% AcOEt-hexane)

出典と根拠

ORDレコード
ord-dba47961fa304c988b59d85a5332202a
出典データセット
uspto-grants-2006_01
特許番号
US06982257B1

反応ノート

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