Hydrochloric Acid → 2-Cyclopentyl-3-methoxycyclohex-3-en-1-one
反応式
[CH:1]1([CH:6]2[C:11]([O:12][CH3:13])=[CH:10][CH2:9][CH:8]=[C:7]2[O:14]C)[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl>CO>[CH:1]1([CH:6]2[C:11]([O:12][CH3:13])=[CH:10][CH2:9][CH2:8][C:7]2=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5]1参加物
4
実験手順
To a solution of 2-cyclopentyl-2,5-dihydro-1,3dimethoxybenzene (5 g, 27 mmol) in methanol (50 mL) was added 2.5% hydrochloric acid (10 mL) dropwise at 0° C. The reaction mixture was stirred for 45 minutes and diluted with 30 mL of ice-cold water. The product was extracted with ether (3×100 mL). The combined organic extract was washed with brine and dried (Na2SO4). Removal of the solvent in vacuo yielded the title compound as light yellow oil (4.3 g, 94.7%).
後処理
- extractionThe product was extracted with ether (3×100 mL)
- extractionThe combined organic extract
- washwas washed with brine
- dry with materialdried (Na2SO4)
- customRemoval of the solvent in vacuo
出典と根拠
- ORDレコード
- ord-e93b9678d5f746a29526b21670272f71
- 出典データセット
- uspto-grants-2006_01
- 特許番号
- US06982260B1
反応ノート
読み込み中…