1-Indanone → Indeno(1,2-b)indole

HRID 1609887

反応式

HRID 1609887 の反応式
[C:1]1(=O)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Cl.[C:12]1(C)[CH:17]=[CH:16][C:15]([NH:18]N)=[CH:14][CH:13]=1>C(O)C.Cl>[CH:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:4]=1[CH:3]=[C:2]1[C:16]3[CH:17]=[CH:12][CH:13]=[CH:14][C:15]=3[N:18]=[C:1]12

参加物

5

反応物 2

HCID 67351-IndanoneHCID 125044-Methylphenylhydrazine monohydrochloride

生成物 1

HCID 12963293Indeno(1,2-b)indole

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

実験手順

A mixture of 1-indanone (30.6 g, 232 mmol) and p-tolylhydrazine hydrochloride (37.0 g, 233 mmol) in ethanol (350 mL) and aqueous HCl (12 N, 18 mL) are heated to reflux for 90 minutes. The mixture is cooled and filtered, and the solid is washed with ethanol (600 mL) followed by 20% aqueous ethanol (400 mL) and finally hexanes (200 mL). The off-white solid is dried under vacuum (36.5 g, 72%).

後処理

  1. temperatureare heated
  2. temperatureto reflux for 90 minutes
  3. temperatureThe mixture is cooled
  4. filtrationfiltered
  5. washthe solid is washed with ethanol (600 mL)
  6. customThe off-white solid is dried under vacuum (36.5 g, 72%)

出典と根拠

ORDレコード
ord-82ddc71cd753491c8dcd622bab0152f9
出典データセット
uspto-grants-2006_01
特許番号
US06982305B2

関連ノート

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