5-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid → 2-Methyl-5-(trifluoromethyl)furan

HRID 1610327ノート

反応式

HRID 1610327 の反応式
[CH3:1][C:2]1[O:6][C:5]([C:7]([F:10])([F:9])[F:8])=[C:4](C(O)=O)[CH:3]=1>N1C2C(=CC=CC=2)C=CC=1.S([O-])([O-])(=O)=O.[Cu+].[Cu+]>[CH3:1][C:2]1[O:6][C:5]([C:7]([F:10])([F:9])[F:8])=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 27821835-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid

生成物 1

HCID 109536882-Methyl-5-(trifluoromethyl)furan収率 54%

試薬・触媒・溶媒 2

HCID 134737Sulfuric acid, copper(1+) salt (1:2)触媒HCID 7047Quinoline溶媒

実験手順

To a solution of 5-methyl-2-(trifluoromethyl)-3-furancarboxylic acid (20 g, 103 mmol) in quinoline (36 ml) was added copper (I) sulfate (1 g, 6.3 mmol). While bubbling nitrogen, the mixture was immersed in an oil bath at 230° C. until gas generation ceased. The generated gas was collected and distilled again to give 2-methyl-5-(trifluoromethyl)furan (8.34 g, 54%).

後処理

  1. customWhile bubbling nitrogen
  2. customthe mixture was immersed in an oil bath at 230° C. until gas generation
  3. customThe generated gas was collected
  4. distillationdistilled again

出典と根拠

ORDレコード
ord-1ad3a181e7444430b968eb54d685f291
出典データセット
uspto-grants-2006_01
特許番号
US06982348B2

反応ノート

読み込み中…