Acetic Acid → 2,2,3,3-Tetrafluoro-1,4-benzodioxane-6-carboxylic acid

HRID 1610617ノート

反応式

HRID 1610617 の反応式
[F:1][C:2]1([F:16])[O:7][C:6]2[CH:8]=C[C:10](C#N)=[CH:11][C:5]=2[O:4][C:3]1([F:15])[F:14].Cl.[C:18]([OH:21])(=[O:20])[CH3:19]>>[F:15][C:3]1([F:14])[O:4][C:5]2[CH:11]=[CH:10][C:19]([C:18]([OH:21])=[O:20])=[CH:8][C:6]=2[O:7][C:2]1([F:1])[F:16]

参加物

4

反応物 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 27766192,2,3,3-Tetrafluoro-1,4-benzodioxane-6-carbonitrile

生成物 1

HCID 222614602,2,3,3-Tetrafluoro-1,4-benzodioxane-6-carboxylic acid

実験手順

To a solution of 2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxine-6-carbonitrile (5.0 g, 21.44 mmol) in acetic acid (20 ml) was added conc. hydrochloric acid (20 ml), and the mixture was heated under reflux overnight. The reaction solution was concentrated, and the precipitated crystals were filtered and washed with water to give the objective substance (4.76 g, 88%).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. concentrationThe reaction solution was concentrated
  4. filtrationthe precipitated crystals were filtered
  5. washwashed with water
  6. customto give the objective substance (4.76 g, 88%)

出典と根拠

ORDレコード
ord-7554ad90166e47ef946e168e466b3561
出典データセット
uspto-grants-2006_01
特許番号
US06982348B2

反応ノート

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