Hydrochloric Acid → HCID 22258297、化合物

HRID 1610826ノート

反応式

HRID 1610826 の反応式
FC1C=CC=CC=1C([O:6][C:7]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[F:31])=[CH:8][C:9]1[N:10](C(=O)C2C=CC=CC=2F)[C:11]([CH3:15])=[C:12]([CH3:14])[N:13]=1)=O.O.[ClH:37]>>[ClH:37].[CH3:14][C:12]1[N:13]=[C:9]([CH2:8][C:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[F:31])=[O:6])[NH:10][C:11]=1[CH3:15]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 695894172-[1-(2-Fluorobenzoyl)-4,5-dimethyl-1H-imidazol-2-yl]-1-(2-fluorophenyl)ethenyl 2-fluorobenzoate

生成物 1

HCID 22258297HCID 22258297、化合物収率 14%

実験手順

12.97 g crude crude compound of Example V are refluxed 1.5 h in 200 ml concentrated hydrochloric acid. The mixture is cooled to rT and 200 mL water are added. The solution is extracted twice with toluene and the aqueous phase is concentrated under vacuum. The residue is stirred with ethanol, filtered, washed once with ethyl acetate and once with petrol ether and dried to yield 1.04 g (14% of th.) 2-(4,5-Dimethyl-1H-imidazol-2-yl)-1-(2-fluorophenyl)ethanone hydrochloride.

後処理

  1. temperatureThe mixture is cooled
  2. extractionThe solution is extracted twice with toluene
  3. concentrationthe aqueous phase is concentrated under vacuum
  4. filtrationfiltered
  5. washwashed once with ethyl acetate and once with petrol ether
  6. customdried

出典と根拠

ORDレコード
ord-860b4b6731194912bc23a629ca07c025
出典データセット
uspto-grants-2006_01
特許番号
US06984646B2

反応ノート

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