Potassium Hydroxide → HCID 22258169、化合物

HRID 1610879ノート

反応式

HRID 1610879 の反応式
[Br:1][C:2]1[N:6]2[C:7](Cl)=[CH:8][CH:9]=[C:10]([C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:12])[C:5]2=[N:4][CH:3]=1.[OH-:20].[K+]>C(O)C>[C:11]([C:10]1[CH:9]=[CH:8][C:7](=[O:20])[N:6]2[C:2]([Br:1])=[CH:3][NH:4][C:5]=12)(=[O:12])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 22258287HCID 22258287、化合物

生成物 1

HCID 22258169HCID 22258169、化合物収率 4.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

40 mg (0.12 mmol) of 3-bromo-5chloroimidazo[1,2-a]pyridin-8-yl)(phenyl)methanone (example L) are dissolved in 5 ml of potassium hydroxide—solution (10% in water) and 5 ml of ethanol. The mixture is stirred for 24 h at rt. The solvent is evaporated under vacuum and water is added to the crude. The solution is extracted for with ethyl acetate. The collected organic phases are reextracted with brine solution and dried over sodium sulfate. The solvent is evaporated under vacuum and the crude is purified over preparative HPLC (RP18-Column, eluent: acetonitrilewater-gradient) to yield 1.6 mg (4.2% of th.) 8-Benzoyl-3-bromoimidazo[1,2-a]pyridin-5(1H)-one.

後処理

  1. customThe solvent is evaporated under vacuum and water
  2. additionis added to the crude
  3. extractionThe solution is extracted for with ethyl acetate
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is evaporated under vacuum
  6. customthe crude is purified over preparative HPLC (RP18-Column, eluent: acetonitrilewater-gradient)

出典と根拠

ORDレコード
ord-260ac36685df41e3966a86263b03f220
出典データセット
uspto-grants-2006_01
特許番号
US06984646B2

反応ノート

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