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HRID 16112作成日:2026年10月25日

(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acid → (2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

https://huagongshe.com/reaction/16112

反応式

関与物質

役割名称HCID仕込み量
反応物(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acidHCID 11539174—
反応物(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acidHCID 67277298—
生成物(2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acidHCID 11538441—

反応手順

The title compound was prepared using the product of example 33 step a) and the product of example 28 step c) by the method of example 32 step b).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07737135B2
出典データセットuspto-grants-2010_06
ORD IDord-dff6b5a0db1547c19bd0363b932ca948
出典メモuspto-grants-2010_06