4-(Pyrrolidin-2-yl)pyridine → (S)-hydroxy-3 (R)-[2-pyridin-4-yl-pyrrolidine-1-carbonyl)-heptanoic acid

反応式

CC1(C)[O:6][C:5](=[O:7])[CH:4]([CH:8]([CH2:12][CH2:13][CH2:14][CH3:15])[C:9]([OH:11])=O)[O:3]1.[NH:17]1[CH2:21][CH2:20][CH2:19][CH:18]1[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1>>[OH:3][C@@H:4]([C@H:8]([C:9]([N:17]1[CH2:21][CH2:20][CH2:19][CH:18]1[C:22]1[CH:23]=[CH:24][N:25]=[CH:26][CH:27]=1)=[O:11])[CH2:12][CH2:13][CH2:14][CH3:15])[C:5]([OH:6])=[O:7]

参加物

反応物 2

HCID 27716644-(Pyrrolidin-2-yl)pyridine

HCID 222565262-(2,2-Dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid

生成物 1

HCID 86587585(S)-hydroxy-3 (R)-[2-pyridin-4-yl-pyrrolidine-1-carbonyl)-heptanoic acid

実験手順

The title compound is prepared from 2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid B-5 and commercially available 4-pyrrolidin-2-yl-pyridine A-5 according to General Procedure B.

出典と根拠

ORDレコード: ord-b1eb30db31a949a2b3e00cc83f8c1740
出典データセット: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06987104B2

反応ノート

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