2-(Bromomethyl)-1,4-difluorobenzene → HCID 15957751、化合物

反応式

[CH2:1]([C:3]1[C:4](=[O:20])[NH:5][C:6](=[O:19])[NH:7][C:8]=1[C:9](=[O:18])[C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[F:21][C:22]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:23]=1[CH2:24]Br>>[F:21][C:22]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:23]=1[CH2:24][N:7]1[C:8]([C:9](=[O:18])[C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:20])[NH:5][C:6]1=[O:19]

参加物

反応物 2

HCID 5228302-(Bromomethyl)-1,4-difluorobenzene

HCID 222565796-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dione

生成物 1

HCID 15957751HCID 15957751、化合物収率 53.7%

実験手順

5-Ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 2,5-difluorobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (214 mg, yield: 53.7%).

出典と根拠

ORDレコード: ord-d1532a9c6baa476a9520df62c32a4815
出典データセット: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06987114B1

反応ノート

読み込み中…