1-Deoxy-1-(methylamino)hexitol → HCID 22252052、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:11]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]I)=[CH:14][CH:13]=3)[CH:10]([CH2:26][CH2:27][CH:28]([C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)[OH:29])[C:9]2=[O:37])=[CH:4][CH:3]=1.[CH3:38][NH:39][CH2:40][CH:41]([OH:50])[CH:42]([OH:49])[CH:43]([OH:48])[CH:44]([OH:47])[CH2:45][OH:46]>CN(C)C=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:11]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][N:39]([CH3:38])[CH2:40][CH:41]([OH:50])[CH:42]([OH:49])[CH:43]([OH:48])[CH:44]([OH:47])[CH2:45][OH:46])=[CH:14][CH:13]=3)[CH:10]([CH2:26][CH2:27][CH:28]([C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)[OH:29])[C:9]2=[O:37])=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
136 mg of 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(6-iodohexyloxy)phenyl]azetidin-2-one are dissolved in 10 ml of absolute dimethylformamide. 172 mg of 6-methylaminohexane-1,2,3,4,5-pentaol are then added, and the reaction solution is stirred at 50° C. for 2.5 h. After concentration using a rotary evaporator and oil pump vacuum at 40° C., the residue is purified by preparative HPLC. The product is obtained as an oil. C37H48F2N2O8 (686) MS (ESI): M+