4-Hydroxybenzoic Acid → 3-Methylpentyl p-hydroxybenzoate

HRID 1612584

反応式

HRID 1612584 の反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[CH3:11][C@@H:12]([CH2:16][CH3:17])[CH2:13][CH2:14]O.S(=O)(=O)(O)O>C1(C)C=CC=CC=1>[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH2:14][CH2:13][CH:12]([CH3:11])[CH2:16][CH3:17])=[O:7])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1354-Hydroxybenzoic AcidHCID 1118Sulfuric AcidHCID 641003(S)-(+)-3-Methyl-1-pentanol

生成物 1

HCID 190183233-Methylpentyl p-hydroxybenzoate収率 80.7%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

13.7 g of p-hydroxybenzoic acid and 11.4 g of (S)-(+)-3-methyl-1-pentanol were refluxed for 10 hours in toluene in the presence of sulfuric acid, while removing out the generated water from the reaction system. Subsequently, the reaction solution was washed with water to remove the sulfuric acid out. The reaction solution was then dried, concentrated, and purified by column chromatography, to obtain 17.8 g of the objective ester compound (liquid state at room temperature ([α]d23 =+7.8° (CHCl3)). (Yield: 80%)

後処理

  1. customwhile removing out the generated water from the reaction system
  2. washSubsequently, the reaction solution was washed with water
  3. customto remove the sulfuric acid out
  4. customThe reaction solution was then dried
  5. concentrationconcentrated
  6. custompurified by column chromatography

出典と根拠

ORDレコード
ord-6bc979b37a944b2d817462a48611bb6f
出典データセット
uspto-grants-1993_03
特許番号
US05190686

関連ノート

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