Potassium Carbonate → 1-(Benzimidazol-2-yl)-4-aminomethylpiperidine

HRID 1613203ノート

反応式

HRID 1613203 の反応式
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].Cl[C:16]1[NH:17][C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1>C1(C)C=CC=CC=1>[N:17]1[C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[NH:20][C:16]=1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][NH2:1])[CH2:4][CH2:5]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 235274-(Aminomethyl)piperidineHCID 785722-Chlorobenzimidazole

生成物 1

HCID 197495451-(Benzimidazol-2-yl)-4-aminomethylpiperidine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

45 g of 4-aminomethylpiperidine are placed in 500 ml of anhydrous toluene in the presence of 55 g of potassium carbonate and of 50 g of 2-chlorobenzimidazole. The mixture is subjected to reflux overnight. Aver evaporation and crystallization of the oily residue, the expected product is obtained after washing with dichloromethane.

後処理

  1. temperatureto reflux overnight
  2. customAver evaporation and crystallization of the oily residue

出典と根拠

ORDレコード
ord-6fcff09a09b247baa4408307d14cdf61
出典データセット
uspto-grants-1993_03
特許番号
US05192775

反応ノート

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