Water → HCID 24838476、化合物

HRID 1613233ノート

反応式

HRID 1613233 の反応式
[CH3:1][C:2]1[N:3]=[C:4]([NH:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[S:5][C:6]=1[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=1.O>C(O)C.COC(O)C.[Ni]>[CH3:1][C:2]1[N:3]=[C:4]([NH:17][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[S:5][C:6]=1[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=1

参加物

5

反応物 2

HCID 962WaterHCID 24838526HCID 24838526、化合物

生成物 1

HCID 24838476HCID 24838476、化合物収率 72.8%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 86746606HCID 86746606、化合物溶媒

実験手順

9.2 g of ethyl (4-methyl-5-(4-nitrobenzyl)thiazol-2-yl)aminoacetate in 500 ml of an ethanol/methoxyethanol mixture are hydrogenated at normal pressure and room temperature in the presence of Raney nickel. After filtration of the catalyst and concentration of the reaction medium, a brown oil is obtained which is taken up with acidified water, the aqueous phase is extracted with chloroform and then rendered basic and the precipitate obtained is filtered off to give 6.1 g of ethyl (4-methyl-5-(4-aminobenzyl)thiazol-2-yl)aminoacetate in the form of a brown solid melting at 116° C.

後処理

  1. filtrationAfter filtration of the catalyst and concentration of the reaction medium
  2. customa brown oil is obtained which
  3. extractionthe aqueous phase is extracted with chloroform
  4. customthe precipitate obtained
  5. filtrationis filtered off

出典と根拠

ORDレコード
ord-eb96a2b7badf488ea8325a712b7613eb
出典データセット
uspto-grants-1993_03
特許番号
US05192781

反応ノート

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