1-Butanol → n-Butyl-2-(o-phenoxyphenyl)hexanoate

HRID 1613259ノート

反応式

HRID 1613259 の反応式
[CH2:1]([OH:5])[CH2:2][CH2:3][CH3:4].[CH3:6][CH2:7][CH2:8][CH2:9][CH:10]([C:24]#N)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.S(=O)(=O)(O)[OH:27]>O>[CH2:1]([O:5][C:24](=[O:27])[CH:10]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:9][CH2:8][CH2:7][CH3:6])[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 3

HCID 2631-ButanolHCID 1118Sulfuric AcidHCID 197756142-(2-Phenoxyphenyl)hexanenitrile

生成物 1

HCID 53887059n-Butyl-2-(o-phenoxyphenyl)hexanoate収率 104.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Into a 500-ml round bottom flask are placed 77.7 g (1 mole) of n-butanol, 36.5 g (0.14 mole) of δ-n-butyl o-phenoxybenzyl cyanide and 14.4 g (0.45 mole) of conc. sulfuric acid. The mixture is heated to reflux overnight. It is then cooled, poured into water and extracted with toluene. The combined extracts are washed with water and dried over MgSO4. Solvent is evaporated to give 50 g of product.

後処理

  1. customInto a 500-ml round bottom flask are placed
  2. temperatureThe mixture is heated
  3. temperatureto reflux overnight
  4. temperatureIt is then cooled
  5. extractionextracted with toluene
  6. washThe combined extracts are washed with water
  7. dry with materialdried over MgSO4
  8. customSolvent is evaporated

出典と根拠

ORDレコード
ord-a818d85f8fc1464b89e62463d1091a23
出典データセット
uspto-grants-1993_03
特許番号
US05192783

反応ノート

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