Sodium Bicarbonate → N-(4-diethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide

HRID 1613287ノート

反応式

HRID 1613287 の反応式
Cl.[CH2:2]([N:4]([CH2:26][CH3:27])[CH2:5][C:6]#[C:7][CH2:8][NH:9][C:10](=[O:25])[C:11](Cl)([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:3].C(=O)(O)[O-:29].[Na+]>O>[CH2:2]([N:4]([CH2:26][CH3:27])[CH2:5][C:6]#[C:7][CH2:8][NH:9][C:10](=[O:25])[C:11]([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)([OH:29])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:3]

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 19775490N-(4-diethylamino-2-butynyl)-2-chloro-2-cyclohexyl-2-phenylacetamide hydrochloride

生成物 1

HCID 14931302N-(4-diethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

N-(4-Diethylamino-2-butynyl)-2-chloro-2-cyclohexyl-2-phenylacetamide hydrochloride (100 mg) was dissolved in water (1 ml) and the solution was refluxed for 20 minutes. After being cooled, the solution was made alkaline (pH 10) with saturated sodium bicarbonate aqueous solution and extracted with ethyl acetate. The extract was washed with sodium chloride aqueous solution, dried over sodium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel with a mixture of chloroform and methanol as an eluent to give N-(4-diethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide (74 mg).

後処理

  1. temperaturethe solution was refluxed for 20 minutes
  2. temperatureAfter being cooled
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with sodium chloride aqueous solution
  5. dry with materialdried over sodium sulfate
  6. customevaporated in vacuo
  7. customThe residue was purified by column chromatography on silica gel with a mixture of chloroform and methanol as an eluent

出典と根拠

ORDレコード
ord-a366e5e07fcd47ab9411e032db897c9e
出典データセット
uspto-grants-1993_03
特許番号
US05192779

反応ノート

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