Cesium carbonate → 1-(6-chloropyrazin-2-yl)-1H-benzimidazole-6-carboxamide

A mixture of 2,6-dichloropyrazine (2.0 g, 13.4 mmol), 1H-benzimidazole-5-carboxamide (2.0 g, 12.3 mmol) and cesium carbonate (5.6 g, 17.2 mmol) in DMF (10 mL) was heated at 90° C. for 3 h. The solution was cooled to RT and diluted with ethyl acetate (20 mL) and filtered. The solid material was washed with chloroform-methanol (20 mL, 4:1) and the combined filtrates concentrated in vacuo. The residue thus obtained (3.02 g) was used without further purification.

1. temperatureThe solution was cooled to RT
2. filtrationfiltered
3. washThe solid material was washed with chloroform-methanol (20 mL, 4:1)
4. concentrationthe combined filtrates concentrated in vacuo
5. customThe residue thus obtained (3.02 g)
6. customwas used without further purification

ORDレコード

ord-45a00e9379fe4e9aa2e1505c54eed664

出典データセット

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07737143B2