4-Methyl-5,6-dihydroquinoline → 5,6,7,8-tetrahydro-7-(N-hydroxy-1-propylamino)-4-methylquinoline

HRID 1613583ノート

反応式

HRID 1613583 の反応式
[CH3:1][C:2]1[C:11]2[CH2:10][CH2:9][CH:8]=[CH:7][C:6]=2[N:5]=[CH:4][CH:3]=1.Cl.[CH2:13]([NH:16][OH:17])[CH2:14][CH3:15]>CO>[OH:17][N:16]([CH2:13][CH2:14][CH3:15])[CH:8]1[CH2:7][C:6]2[N:5]=[CH:4][CH:3]=[C:2]([CH3:1])[C:11]=2[CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 121336204-Methyl-5,6-dihydroquinolineHCID 12355438N-propylhydroxylamine hydrochloride

生成物 1

HCID 148359505,6,7,8-tetrahydro-7-(N-hydroxy-1-propylamino)-4-methylquinoline収率 73.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

This compound was prepared from the product of Step 6 (4.5 g, 30 mmol), 1-propylhydroxylamine hydrochloride (6 g, 55 mmol), and methanol (20 ml) by the method outlined in Example 10. The crude material was recrystallised from cyclohexane to give the product (4.85 g).

後処理

  1. customThe crude material was recrystallised from cyclohexane

出典と根拠

ORDレコード
ord-e083ec29763c4624be6072bb433d1a81
出典データセット
uspto-grants-1993_03
特許番号
US05194439

反応ノート

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