2,6-Dichloropyrazine → 6-chloro-N-methyl-N-[(1S)-1-phenylethyl]pyrazin-2-amine
反応式
[CH3:1][NH:2][C@H:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:4].Cl[C:12]1[CH:17]=[N:16][CH:15]=[C:14]([Cl:18])[N:13]=1>>[Cl:18][C:14]1[N:13]=[C:12]([N:2]([CH3:1])[C@H:3]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:4])[CH:17]=[N:16][CH:15]=1参加物
3
実験手順
In an analogous fashion to example 1, N-methyl-N-[(1S)-1-phenylethyl]amine (0.27 g, 2.0 mmol) was condensed with 2,6-dichloropyrazine (0.36 g, 2.4 mmol), to furnish the desired product as a light brown solid (192 mg, 39%).
出典と根拠
- ORDレコード
- ord-863f27e57344459eacf6de47048dfb92
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07737143B2
反応ノート
読み込み中…