1-Aminotetralin, (S)- → 1-{6[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]pyrazin-2-yl}-1H-benzimidazole-6-carbonitrile
反応式
ClC1N=C(N2C3C=CC(C#N)=CC=3N=C2)C=NC=1.Cl[C:20]1[N:25]=[C:24]([N:26]2[C:30]3[CH:31]=[C:32]([C:35]#[N:36])[CH:33]=[CH:34][C:29]=3[N:28]=[CH:27]2)[CH:23]=[N:22][CH:21]=1.[C@@H:37]1([NH2:47])[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH2:40][CH2:39][CH2:38]1>>[C@@H:37]1([NH:47][C:20]2[N:25]=[C:24]([N:26]3[C:30]4[CH:31]=[C:32]([C:35]#[N:36])[CH:33]=[CH:34][C:29]=4[N:28]=[CH:27]3)[CH:23]=[N:22][CH:21]=2)[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH2:40][CH2:39][CH2:38]1参加物
4
実験手順
In an analogous fashion to Example 1, an approximately 1:1 mixture of 1-(6-chloropyrazin-2-yl)-1H-benzimidazole-5-carbonitrile and 1-(6-chloropyrazin-2-yl)-1H-benzimidazole-6-carbonitrile (100 mg, 0.39 mmol) was condensed with (1S)-1,2,3,4-tetrahydronaphthalen-1-amine (69 mg, 0.47 mmol). The product was obtained as a mixture of regioisomers which were separated by column chromatography using dichloromethane-methanol (95:5) as eluant. From the less polar fractions 1-{6[(1S)-1,2,3,4-tetrahydronaphthalen-1-ylamino]pyrazin-2-yl}-1H-benzimidazole-6-carbonitrile was obtained as a yellow semi-solid (26 mg).