Hydrochloric Acid → 9,21-Dihydroxypregn-4-ene-3,20-dione

HRID 1613975ノート

反応式

HRID 1613975 の反応式
Cl.C(N/[C:5](=[C:8]1/[CH2:9][CH2:10][C@@H:11]2[C@:25]/1([CH3:26])[CH2:24][CH2:23][C@@:22]1([OH:27])[C@H:12]2[CH2:13][CH:14]=[C:15]2[C@:20]1([CH3:21])[CH2:19][CH2:18][C:17]([O:28]C)=[CH:16]2)/[CH2:6][OH:7])=O.C[OH:31]>>[OH:27][C@:22]12[CH2:23][CH2:24][C@@:25]3([CH3:26])[C@@H:11]([CH2:10][CH2:9][C@@H:8]3[C:5](=[O:31])[CH2:6][OH:7])[C@@H:12]1[CH2:13][CH2:14][C:15]1[C@:20]2([CH3:21])[CH2:19][CH2:18][C:17](=[O:28])[CH:16]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 86746638(20Z)-20-Formamido-3-methoxypregna-3,5,17(20)-triene-9alpha,21-diol

生成物 1

HCID 571918849,21-Dihydroxypregn-4-ene-3,20-dione

実験手順

Aqueous 5N hydrochloric acid (1 ml) was added to a stirred solution of (20Z)-20-formamido-3-methoxypregna-3,5,17(20)-triene-9α,21-diol (70 mg) in methanol (4 ml). The reaction mixture was stirred at room temperature for 1 hour, then extracted with ethyl acetate. The organic extract was washed with an aqueous sodium bicarbonate solution, twice with water, dried and concentrated under reduced pressure to afford the title compound.

後処理

  1. extractionextracted with ethyl acetate
  2. extractionThe organic extract
  3. washwas washed with an aqueous sodium bicarbonate solution, twice with water
  4. customdried
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-dde6bdac6ce64edeb88aad39c90732a4
出典データセット
uspto-grants-1993_03
特許番号
US05194602

反応ノート

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