Sulfuryl chloride → 4-Chloro-2-difluoromethoxyimino-3-oxobutyric acid

HRID 1614076ノート

反応式

HRID 1614076 の反応式
[F:1][CH:2]([F:16])[O:3][N:4]=[C:5]([C:13](=[O:15])[CH3:14])[C:6]([O:8]C(C)(C)C)=[O:7].S(Cl)([Cl:20])(=O)=O>C(O)(=O)C>[Cl:20][CH2:14][C:13](=[O:15])[C:5](=[N:4][O:3][CH:2]([F:16])[F:1])[C:6]([OH:8])=[O:7]

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 54363554Tert-butyl 2-difluoromethoxyimino-3-oxobutyrate

生成物 1

HCID 539879194-Chloro-2-difluoromethoxyimino-3-oxobutyric acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of tert-butyl 2-difluoromethoxyimino-3-oxobutyrate (5.0 g) in acetic acid (5 ml) was added sulfuryl chloride (8.5 ml). The mixture was stirred at 60°-63° C. for 7 hours. The solvent was evaporated in vacuo to give 4-chloro-2-difluoromethoxyimino-3-oxobutyric acid (4.5 g) as a glassy mass.

後処理

  1. customThe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-8601cfb2141b430dbbf173161b737673
出典データセット
uspto-grants-1993_03
特許番号
US05194432

反応ノート

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