1,2-Dichloroethane → 1,1'-Dimethyl 2,2'-oxybis(acetate)

HRID 1614519

反応式

HRID 1614519 の反応式
[C:1]([OH:9])(=[O:8])[CH2:2][O:3][CH2:4][C:5]([OH:7])=O.[CH3:10][OH:11].Cl[CH2:13]CCl>>[CH3:10][O:11][C:5](=[O:7])[CH2:4][O:3][CH2:2][C:1]([O:9][CH3:13])=[O:8]

参加物

4

反応物 3

HCID 111,2-DichloroethaneHCID 887MethanolHCID 8088Diglycolic Acid

生成物 1

HCID 2018771,1'-Dimethyl 2,2'-oxybis(acetate)

実験手順

Diglycolic acid (67.05 g, 0.5 mol) was dissolved in a mixture of methanol (122 ml, 30 mol) and 1,2-dichloroethane (150 ml). KSF-catalyst (Aldrich) (2.5 g) was added and the mixture was refluxed for 15 hours. The mixture was cooled to ambient temperature, filtered through alumina, washed with aqueous saturated sodium hydrogen carbonate (100 ml) and dried over magnesium sulphate. The solvent was evaporated and diglycolic acid dimethyl ester was isolated after distillation as a colourless oil.

後処理

  1. additionKSF-catalyst (Aldrich) (2.5 g) was added
  2. temperaturethe mixture was refluxed for 15 hours
  3. filtrationfiltered through alumina
  4. washwashed with aqueous saturated sodium hydrogen carbonate (100 ml)
  5. dry with materialdried over magnesium sulphate
  6. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-0511df2ffccf40bc98e811058e3432a5
出典データセット
uspto-grants-1993_03
特許番号
US05198208

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